| A model of non-uniform lung parenchyma distortion. | |
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MedLine Citation:
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PMID: 16439235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A finite element model of mammalian lung parenchyma is used to study the effect of large non-uniform distortions on lung elastic behaviour. The non-uniform distortion is a uni-axial stretch from an initial state of uniform pressure expansion. For small distortions, the parenchymal properties are linearly isotropic and described by two elastic moduli. However, for large distortions, the parenchyma has anisotropic non-linear elastic properties described by five independent elastic moduli dependent on the degree of distortion; they are computed for a range of distortions and initial pressures. Ez, the Young's modulus in the direction of stretch, increases significantly with distortion (epsilon(z)) while Ex, the Young's modulus in the plane perpendicular to the stretch, is approximately constant. The greater the initial pressure, the bigger the difference between the two moduli at larger distortion strains. The shear modulus G(xz) is approximately independent of degree of distortion except at the highest initial pressure. The Poisson's ratio, nu(xz) is approximately constant with distortion strain for lower initial pressures, but increases significantly with epsilon(z) at higher pressures. Model predictions of the relation between G(xz) and initial uniform inflation pressure show a good correlation with reported experimental data for small distortion strains in a range of species. The model also exhibits similar behaviour to the experimentally measured uni-axial large deformations of a tri-axially pre-loaded block of parenchyma (Hoppin et al., 1975, Journal of Applied Physiology 39, 742-751). |
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Authors:
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E Denny; R C Schroter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomechanics Volume: 39 ISSN: 0021-9290 ISO Abbreviation: J Biomech Publication Date: 2006 |
Date Detail:
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Created Date: 2006-01-27 Completed Date: 2006-06-12 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 652-63 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, Imperial College London, Exhibition Road, South Kensington Campus, London SW7 2AZ, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisotropy Computer Simulation Elasticity Finite Element Analysis Humans Lung / physiology* Models, Biological* Nonlinear Dynamics Pressure Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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