| A model of metabolic changes in respiration-deficient human cells. | |
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MedLine Citation:
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PMID: 17559336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells lacking aerobic metabolism because of damaged mtDNA accumulate in many postmitotic tissues in the course aging. Although being only a small fraction of cells, they might play a major role in oxidative stress affecting the whole body. However, it remains unclear how such cells, which are under normal circumstances dependent on aerobic metabolism, are able to survive for decades in vivo. Here a new model is presented that proposes a coexistence of anaerobic glycolysis and a partly reversed TCA cycle. Succinate plays a key role in the changed metabolic pathways because it has to be exported by the cell. This hypothesis supports the view that some respiration-deficient cells are able to survive permanently within the body and contribute to human aging. |
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Authors:
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F Mathias Bollmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rejuvenation research Volume: 10 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-07 Completed Date: 2007-11-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
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Gymnasium Carolinum, Osnabrück, Germany. f.mathiasbollmann@web.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Cell Aging* Cell Respiration DNA, Mitochondrial / metabolism* Glycolysis Humans Models, Biological Models, Theoretical Oxidative Stress Oxygen / metabolism* Oxygen Consumption* Physiological Phenomena Succinic Acid / metabolism Tricarboxylic Acids / chemistry |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial; 0/Tricarboxylic Acids; 110-15-6/Succinic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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