Document Detail


A model for loading-dependent growth, development, and adaptation of tendons and ligaments.
MedLine Citation:
PMID:  9593203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The geometric and material properties of tendons and ligaments change during growth and development. While some of the changes occur in the absence of mechanical loading, normal development requires the mechanical stimulus provided by normal physical activity. We have developed an analytical framework for quantitatively describing changes in uniaxial tendon and ligament properties throughout ontogeny. In our approach, cross-sectional area, modulus, and strength undergo baseline levels of development due to inherent time-dependent biological influences. The properties also change in response to mechanobiological influences by adapting to maintain a constant daily strain stimulus under changing load conditions. We have implemented a computer algorithm based on these concepts and obtained results consistent with experimental observations of normal tendon and ligament growth and development reported by other investigators. Additional results suggest that these concepts can also explain tendon and ligament adaptation to increased or decreased loading experienced during development.
Authors:
T A Wren; G S Beaupré; D R Carter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of biomechanics     Volume:  31     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-07-17     Completed Date:  1998-07-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-14     Citation Subset:  IM; S    
Affiliation:
Rehabilitation Research & Development Center, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA. wren@bones.stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Biomechanics
Computer Simulation
Humans
Ligaments / growth & development*,  physiology*
Models, Biological*
Tendons / growth & development*,  physiology*
Weight-Bearing / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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