Document Detail


A model for isotopic sampling and administration in constant infusion experiments: a test with 13C-palmitate.
MedLine Citation:
PMID:  6846232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have proposed and tested a model that demonstrates the importance of the site of isotopic sampling relative to the site of infusion for the constant infusion of labeled palmitate. Palmitate enrichment is significantly increased downstream from the infusion catheter. However, palmitate production is underestimated unless sampling is performed upstream from the catheter. There was no significant difference between upstream sampling from the femoral vein versus the right heart, whereas the downstream arterial sampling gave significantly higher enrichments compared to the femoral vein. We have also discussed the importance of sampling sites for other substrates and the constraints that this model places on the design and interpretation of whole body primed constant infusion experiments using labeled substrates.
Authors:
R D Goodenough; R R Wolfe
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  37     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1004-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Circulation
Blood Specimen Collection / methods*
Carbon Isotopes*
Dogs
Female
Infusions, Parenteral*
Kinetics
Male
Models, Biological
Palmitates / diagnostic use*
Palmitic Acids / diagnostic use*
Grant Support
ID/Acronym/Agency:
GM00455-03/GM/NIGMS NIH HHS; GM007-035/GM/NIGMS NIH HHS; GM21700-07/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Palmitates; 0/Palmitic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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