Document Detail

A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression.
MedLine Citation:
PMID:  11080099     Owner:  NLM     Status:  MEDLINE    
In response to exercise performed before or after altitude decompression, physiological changes are suspected to affect the formation and growth of decompression bubbles. We hypothesized that the work to change the size of a bubble is done by gas pressure gradients in a macro- and microsystem of thermodynamic forces and that the number of bubbles formed through time follows a Poisson process. We modeled the influence of tissue O(2) consumption on bubble dynamics in the O(2) transport system in series against resistances, from the alveolus to the microsystem containing the bubble and its surrounding tissue shell. Realistic simulations of experimental decompression procedures typical of actual extravehicular activities were obtained. Results suggest that exercise-induced elevation of O(2) consumption at altitude leads to bubble persistence in tissues. At the same time, exercise-enhanced perfusion leads to an overall suppression of bubble growth. The total volume of bubbles would be reduced unless increased tissue motion simultaneously raises the rate of bubble formation through cavitation processes, thus maintaining or increasing total bubble volume, despite the exercise.
P P Foster; A H Feiveson; R Glowinski; M Izygon; A M Boriek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  279     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R2304-16     Citation Subset:  IM    
Department of Medicine, Baylor College of Medicine, Houston 77030, USA.
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MeSH Terms
Computer Simulation*
Exercise / physiology*
Gases / metabolism*
Models, Biological*
Oxygen Consumption
Poisson Distribution
Respiratory Mechanics
Stochastic Processes
Reg. No./Substance:

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