Document Detail

A model for human ventricular tissue.
MedLine Citation:
PMID:  14656705     Owner:  NLM     Status:  MEDLINE    
The experimental and clinical possibilities for studying cardiac arrhythmias in human ventricular myocardium are very limited. Therefore, the use of alternative methods such as computer simulations is of great importance. In this article we introduce a mathematical model of the action potential of human ventricular cells that, while including a high level of electrophysiological detail, is computationally cost-effective enough to be applied in large-scale spatial simulations for the study of reentrant arrhythmias. The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. The model includes a basic calcium dynamics, allowing for the realistic modeling of calcium transients, calcium current inactivation, and the contraction staircase. We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed rectifier currents. Our model reproduces the experimentally observed data on action potential duration restitution, which is an important characteristic for reentrant arrhythmias. The conduction velocity restitution of our model is broader than in other models and agrees better with available data. Finally, we model the dynamics of spiral wave rotation in a two-dimensional sheet of human ventricular tissue and show that the spiral wave follows a complex meandering pattern and has a period of 265 ms. We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue.
K H W J ten Tusscher; D Noble; P J Noble; A V Panfilov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-12-04
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  286     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-04-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1573-89     Citation Subset:  IM    
Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands.
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MeSH Terms
Action Potentials / physiology
Arrhythmias, Cardiac / physiopathology
Cell Membrane / physiology
Computer Simulation
Delayed Rectifier Potassium Channels
Endocardium / physiology
Heart / physiology*
Heart Rate / physiology
Ion Channel Gating / physiology
Membrane Potentials / physiology
Models, Biological
Myocardium / cytology,  metabolism
Myocytes, Cardiac / physiology
Pericardium / physiology
Potassium Channels / physiology
Potassium Channels, Voltage-Gated*
Sodium Channels / physiology
Ventricular Function
Reg. No./Substance:
0/Delayed Rectifier Potassium Channels; 0/Potassium Channels; 0/Potassium Channels, Voltage-Gated; 0/Sodium Channels
Comment In:
Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H453; author reply H453-4   [PMID:  15598875 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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