Document Detail


A model of the heterogeneity of red cell hemoglobin concentration.
MedLine Citation:
PMID:  4075788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of red cell hemoglobin concentration has been developed and computer stimulations performed to investigate quantitatively the relationship among the intraindividual heterogeneities of cell hemoglobin content, volume, and hemoglobin concentration. In the model, the cell volume and hemoglobin content frequency distributions and their joint distributions are described by Gaussian probability distributions. The frequency distributions of cell hemoglobin concentration are determined from the joint probability distributions by summing the joint probabilities of the variate pairs the ratios of which equal the specified concentration. For the parameter values considered, the mean cell hemoglobin concentration closely approximates the average (i.e., statistical mean) concentration. The heterogeneity of cell hemoglobin concentration increases with increasing coefficients of variation of cell hemoglobin content and cell volume and with decreasing correlation coefficients. When the correlation coefficient is greater than 0.7, cell hemoglobin concentration shows less relative dispersion than the component indices.
Authors:
D A Noe; W R Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Computers and biomedical research, an international journal     Volume:  18     ISSN:  0010-4809     ISO Abbreviation:  Comput. Biomed. Res.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-28     Completed Date:  1986-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100331     Medline TA:  Comput Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Erythrocyte Indices
Erythrocyte Volume
Erythrocytes / analysis*
Hemoglobins / analysis*
Models, Biological
Statistics as Topic
Grant Support
ID/Acronym/Agency:
HL01601/HL/NHLBI NIH HHS; HL24898/HL/NHLBI NIH HHS; T32HL07525/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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