Document Detail

A model of the factors affecting interstitial volume in oedema. Part III: Partial derivatives and integrals at various volumes.
MedLine Citation:
PMID:  8400154     Owner:  NLM     Status:  MEDLINE    
The effects of the individual Factors controlling interstitial volume vary between the different steady-states. Partial derivatives of volume with respect to each Factor show only the effects near the steady-state. In passing from one steady-state to another, these partial derivatives vary greatly. The total effects of a Factor are those of the integral of the partial derivative from the initial steady-state to the final one. The simplest way to measure a Factor's total effect is by setting it to zero and observing the difference in tissue volume when the model is perturbed. Thus, to find the effect of proteolysis in lymphoedema, for example, let proteolysis = 0 and compare the final volume in lymphoedema with that when proteolysis is allowed to occur. While the effect of proteolysis is important in lymphoedema, it is of minimal importance in trauma or normal condition. It is again important if proteolysis is increased by benzo-pyrones. There is little correlation between a partial derivative at a steady-state and the integral of this from normal to the state. In low-to-moderate oedemas, many Factors influence the fluid volume. When this volume becomes very large, all Factors except tissue hydrostatic pressure decrease in importance. Tissue hydrostatic pressure can increase indefinitely and is the ultimate reason that oedemas do not increase without limit.
J R Casley-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biorheology     Volume:  30     ISSN:  0006-355X     ISO Abbreviation:  Biorheology     Publication Date:    1993 Mar-Apr
Date Detail:
Created Date:  1993-11-18     Completed Date:  1993-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372526     Medline TA:  Biorheology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93-105     Citation Subset:  IM    
Henry Thomas Laboratory, University of Adelaide, Australia.
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MeSH Terms
Edema / physiopathology*
Extracellular Space / physiology*
Lymphedema / physiopathology
Models, Biological*
Models, Theoretical*
Proteins / metabolism
Vascular Diseases / physiopathology
Wounds and Injuries / physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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