Document Detail

A model of the differentiation and relative incidence of glandular versus squamous cell neoplasia of the uterine cervix: connection between incidence and etiology.
MedLine Citation:
PMID:  18704774     Owner:  NLM     Status:  MEDLINE    
It has remained unclear why cervical adenocarcinoma, as observed in consecutive screening, has rapidly increased during the past decades, while at the same time both that of squamous cell carcinoma (SCC) and the combined toll of adeno- and SCC have consistently decreased. Here it is argued that this might be ascribed to coitus-related changes in the cervicovaginal milieu, where the target cells become infected through a coital act. Frequent alterations in vaginal acidity and changing sexual habits in the era after the oral contraceptive pills and even after the introduction of erectile dysfunction medication, contribute to the pathogenetic scene.
Pentti A Leppäluoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  IM    
Tavintie, Tampere, Finland.
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MeSH Terms
Adenocarcinoma / epidemiology,  etiology*,  pathology
Carcinoma, Squamous Cell / epidemiology,  etiology*,  pathology
Contraceptives, Oral, Hormonal
Europe / epidemiology
Models, Biological
Risk Factors
Sexual Behavior
Uterine Cervical Neoplasms / epidemiology,  etiology*,  pathology
Reg. No./Substance:
0/Contraceptives, Oral, Hormonal

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