Document Detail


A model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells.
MedLine Citation:
PMID:  1059118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When [3H]thymidine is added to HeLa cells grown in thymidine-free medium it is incorporated into DNA almost immediately at full specific activity, blocking any further incorporation of de novo synthesized thymidine nucleotides. Apparently, de novo nucleotide pools [Baumunk, C.N. & Friedman, D.L. (1971) Cancer Res. 31, 1930--35] and salvage nucleotide pools are compartmentalized in HeLa cells. After one generation in the presence of thymidine, the cells begin utilizing nucleotides from both pools to about equal extent.
Authors:
D Kuebbing; R Werner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  72     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-02-02     Completed Date:  1976-02-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3333-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA / biosynthesis
Hela Cells / metabolism*
Kinetics
Models, Biological
Thymidine / metabolism*
Chemical
Reg. No./Substance:
50-89-5/Thymidine; 9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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