Document Detail

A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia.
MedLine Citation:
PMID:  17435324     Owner:  NLM     Status:  MEDLINE    
The three basic cell types in the migrating slug of Dictyostelium discoideum show differential chemotactic response to cyclic AMP (cAMP) and differential sensitivity to suppression of the chemotaxis by ammonia.The values of these parameters indicate a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types.We present a model that explains the localization of the three cell types within the slug based on these chemotactic differences and on the maturation of their chemotactic properties.
Ira N Feit; Jeffrey Pawlikowski; Caroline Zawilski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of biosciences     Volume:  32     ISSN:  0250-5991     ISO Abbreviation:  J. Biosci.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2008-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100809     Medline TA:  J Biosci     Country:  India    
Other Details:
Languages:  eng     Pagination:  329-38     Citation Subset:  IM    
Franklin and Marshall College, Lancaster, PA 17603, USA.
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MeSH Terms
Ammonia / toxicity
Cell Differentiation / physiology*
Chemotactic Factors / metabolism*
Chemotaxis / drug effects*
Cyclic AMP / metabolism*
Dictyostelium / cytology,  physiology*
Models, Biological*
Reg. No./Substance:
0/Chemotactic Factors; 60-92-4/Cyclic AMP; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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