Document Detail

A model approach to the adaptation of cardiac structure by mechanical feedback in the environment of the cell.
MedLine Citation:
PMID:  8540398     Owner:  NLM     Status:  MEDLINE    
The uniformity of the mechanical load of the cardiac fibers in the wall is maintained by continuous remodeling. In this proposed model the myocyte changes direction in optimizing systolic sarcomere shortening. Early systolic stretch and contractility increases the mass of contractile proteins. Cyclic strain of the myocardial tissue diminishes passive stiffness, resulting in the control of ventricular end-diastolic volume. Utilizing these rules of remodeling in our mathematical model yields that the natural helical pathways of the myocardial fibers in the wall are formed automatically.
T Arts; F W Prinzen; L H Snoeckx; R S Reneman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  382     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-02     Completed Date:  1996-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-28     Citation Subset:  IM; S    
Department of Biophysics, Cardiovascular Research Institute Maastricht, University of Limburg, The Netherlands.
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MeSH Terms
Adaptation, Physiological
Heart / physiology*
Models, Biological
Myocardial Contraction / physiology*
Stress, Mechanical

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