| A model for acute carbon monoxide poisoning in conscious rats. | |
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MedLine Citation:
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PMID: 8840478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These experiments were designed to establish an animal model of acute carbon monoxide (CO) poisoning in awake habituated rats. On the day before exposure, under a brief anesthesia, a Levine preparation (unilateral common carotid artery occlusion) was performed on group 1 (n = 8) and 2 (n = 28), but not on group 3 rats (n = 8). Group 1 rats were exposed to air as control. Groups 2 and 3 rats were exposed to 0.27% CO in air for 60 min [carboxyhemoglobin (HbCO) = 70%] followed by a 2-day recovery in air. The Levine preparation per se did not induce any detectable physiologic effects on group 1 rats. Identical cardiovascular and metabolic responses to CO occurred in groups 2 and 3. After the CO exposure, all group 3 rats lived for 2 days with normal neurologic index (NI). In group 2 (n = 25 post-CO), 84% of the rats showed increased NI and edema of the ipsilateral cerebral hemisphere, and 76% of the rats died 8.7 +/- 1.7 h after the CO exposure. NI correlated with the brain edema (rs = 0.748, P < 0.001) and inversely correlated with the survival time after the CO exposure (rs = -0.777, P < 0.001). We therefore may conclude that exposure of the Levine-prepared rats to 0.27% CO in air for 60 min will provide a valuable model for testing of different treatments for CO poisoning. |
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Authors:
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J Jiang; I Tyssebotn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc Volume: 23 ISSN: 1066-2936 ISO Abbreviation: Undersea Hyperb Med Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-10-31 Completed Date: 1996-10-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9312954 Medline TA: Undersea Hyperb Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, University of Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Bradycardia / physiopathology Brain Edema Carbon Dioxide / blood Carbon Monoxide Poisoning* / blood, physiopathology Cause of Death Disease Models, Animal* Heart Rate / physiology Male Oxygen / blood Rats Rats, Wistar Survival Rate |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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