| The mitral annular middiastolic velocity curve: functional correlates and clinical significance in patients with left ventricular hypertrophy. | |
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MedLine Citation:
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PMID: 17658726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Little is known regarding the tissue Doppler characteristics and clinical significance of mitral annular motion during diastasis (L' wave). METHODS: In consecutive patients with left ventricular hypertrophy and normal ejection fraction, standard Doppler and Doppler tissue imaging were performed. Patients were followed up for heart failure (HF) hospitalization. RESULTS: Of 177 patients, 53 (30%) had an L', detected most frequently at the lateral mitral annulus, whereas 35 (20%) had middiastolic transmitral flow (L wave), which almost invariably coexisted with the L'. The L' predicted increased left ventricular filling pressure with 74% sensitivity and 82% specificity, and increased risk of future HF (hazard ratio 3.9 [P = .030]), even after adjusting for baseline clinical differences (hazard ratio 6.5 [P = .024]). When associated with an L wave, HF risk increased further. CONCLUSIONS: Middiastolic annular motion, detectable in almost a third of patients with left ventricular hypertrophy, may be an early marker of diastolic dysfunction and a prognostic marker for HF. |
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Authors:
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Carolyn S P Lam; Lin Han; Jae K Oh; Hong Yang; Lieng H Ling |
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Publication Detail:
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Type: Journal Article Date: 2007-07-20 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 21 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 165-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity Cohort Studies Confidence Intervals Diastole / physiology Echocardiography, Doppler, Pulsed* Female Follow-Up Studies Heart Failure / physiopathology* Humans Hypertrophy, Left Ventricular / physiopathology, ultrasonography* Male Middle Aged Mitral Valve / physiopathology*, ultrasonography Odds Ratio Probability Proportional Hazards Models Prospective Studies Risk Assessment Severity of Illness Index Stroke Volume / physiology* Ventricular Dysfunction, Left / physiopathology, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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