| The mitochondrial citrate carrier: a new player in inflammation. | |
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MedLine Citation:
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PMID: 21787310 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The citrate carrier (CIC) catalyzes the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. Herein we show that CIC mRNA and protein markedly increase in LPS-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of nitric oxide, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation. |
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Authors:
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Vittoria Infantino; Paolo Convertini; Liana Cucci; Maria Antonietta Panaro; Maria Antonietta Di Noia; Rosa Calvello; Ferdinando Palmieri; Vito Lacobazzi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-25 |
Journal Detail:
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Title: The Biochemical journal Volume: - ISSN: 1470-8728 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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