| The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2. | |
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MedLine Citation:
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PMID: 14758801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The article highlighted in this issue is "Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor" by Donna E. Muscarella, Kerry A. O'Brien, Ann T. Lemley, and Stephen E Bloom from Cornell University in Ithaca, NY (pp. 66-73). The following brief review summarizes their findings, highlights the novel biological model and experimental approach used, and explores potential mechanistic and therapeutic implications of these findings. |
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Authors:
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Lawrence H Lash |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: 74 ISSN: 1096-6080 ISO Abbreviation: Toxicol. Sci. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2004-02-03 Completed Date: 2004-03-02 Revised Date: 2010-09-17 |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1-3 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA. l.h.lash@wayne.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects*,
genetics* Cell Line, Tumor Drug Resistance, Neoplasm / genetics* Genes, bcl-2 / genetics* Humans Lymphoma, B-Cell / drug therapy* Mitochondria / drug effects, metabolism* Receptors, GABA-A / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, GABA-A |
| Comments/Corrections | |
Comment On:
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Toxicol Sci. 2003 Jul;74(1):66-73
[PMID:
12730627
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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