Document Detail


The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2.
MedLine Citation:
PMID:  14758801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The article highlighted in this issue is "Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor" by Donna E. Muscarella, Kerry A. O'Brien, Ann T. Lemley, and Stephen E Bloom from Cornell University in Ithaca, NY (pp. 66-73). The following brief review summarizes their findings, highlights the novel biological model and experimental approach used, and explores potential mechanistic and therapeutic implications of these findings.
Authors:
Lawrence H Lash
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  74     ISSN:  1096-6080     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-03-02     Revised Date:  2010-09-17    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA. l.h.lash@wayne.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*,  genetics*
Cell Line, Tumor
Drug Resistance, Neoplasm / genetics*
Genes, bcl-2 / genetics*
Humans
Lymphoma, B-Cell / drug therapy*
Mitochondria / drug effects,  metabolism*
Receptors, GABA-A / drug effects*
Chemical
Reg. No./Substance:
0/Receptors, GABA-A
Comments/Corrections
Comment On:
Toxicol Sci. 2003 Jul;74(1):66-73   [PMID:  12730627 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  New perspectives on paracetamol
Next Document:  Idiopathic primary pulmonary hemosiderosis: treatment with cyclophosphamide and prednisone