Document Detail

Is mitochondrial antibody diagnostic of primary biliary cirrhosis?
MedLine Citation:
PMID:  7215944     Owner:  NLM     Status:  MEDLINE    
In a series of 218 patients diagnosed as having primary biliary cirrhosis only nine exhibited a negative serum mitochondrial antibody. On examining additional specimens from these patients, seven were found to be positive, giving a final incidence of greater than 99%. The two patients whose sera remained negative for the mitochondrial antibody had liver histology compatible with the diagnosis of primary biliary cirrhosis, but a firm diagnosis could not be reached. Three additional mitochondrial antibody positive subjects who were asymptomatic and exhibited normal serum alkaline phosphatase were shown on liver biopsy to have stage I primary biliary cirrhosis. The presence of a positive serum mitochondrial antibody in a patient with or without abnormalities in liver function tests strongly suggests the diagnosis of primary biliary cirrhosis.
L E Munoz; H C Thomas; P J Scheuer; D Doniach; S Sherlock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  22     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / blood
Autoantibodies / analysis*
Cell Nucleus / immunology
Liver / pathology
Liver Cirrhosis, Biliary / diagnosis*,  immunology,  pathology
Middle Aged
Mitochondria / immunology*
Muscle, Smooth / immunology
Thyroid Gland / immunology
Reg. No./Substance:
0/Autoantibodies; EC Phosphatase

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