Document Detail

The missing link: mul1 signals mitophagy and muscle wasting.
MedLine Citation:
PMID:  23140636     Owner:  NLM     Status:  In-Data-Review    
FoxO3 regulates the transcription of autophagy-related genes that induce mitophagy in muscle wasting. In this issue of Cell Metabolism, Lokireddy et al. (2012) now show that the mitochondrial ubiquitin protein ligase 1 (Mul1) polyubiquitinates the mitochondrial fusion protein Mfn2 and is necessary for FoxO3- and lysosomal-dependent mitophagy in muscle atrophy.
Didier Attaix; Daniel Taillandier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  16     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
INRA, UMR 1019 Nutrition Humaine et Clermont Université, UFR Médecine, UMR 1019 Nutrition Humaine, 63000 Clermont-Ferrand, France. Electronic address:
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