| The missing link: mul1 signals mitophagy and muscle wasting. | |
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MedLine Citation:
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PMID: 23140636 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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FoxO3 regulates the transcription of autophagy-related genes that induce mitophagy in muscle wasting. In this issue of Cell Metabolism, Lokireddy et al. (2012) now show that the mitochondrial ubiquitin protein ligase 1 (Mul1) polyubiquitinates the mitochondrial fusion protein Mfn2 and is necessary for FoxO3- and lysosomal-dependent mitophagy in muscle atrophy. |
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Authors:
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Didier Attaix; Daniel Taillandier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell metabolism Volume: 16 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 551-2 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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INRA, UMR 1019 Nutrition Humaine et Clermont Université, UFR Médecine, UMR 1019 Nutrition Humaine, 63000 Clermont-Ferrand, France. Electronic address: didier.attaix@clermont.inra.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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