Document Detail


The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription.
MedLine Citation:
PMID:  7773292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) is inherited as a polygenic trait. One of the loci implicated in IDDM is a polymorphic minisatellite 5' of the human insulin (INS) gene on chromosome 11. This insulin-linked polymorphic region (ILPR) is composed of tandemly repeated sequences, which fall into three size classes: IDDM is strongly associated with short ILPR alleles. We now show that the ILPR is capable of transducing a transcriptional signal in pancreatic beta-cells, with a long ILPR possessing greater activity than a short ILPR. The ILPR contains numerous high-affinity binding sites for the transcription factor Pur-1, and transcriptional activation by Pur-1 is modulated by naturally occurring sequences in the ILPR. Our results demonstrate a possible function for this unique minisatellite, which may have implications for type 1 diabetes.
Authors:
G C Kennedy; M S German; W J Rutter
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature genetics     Volume:  9     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-12     Completed Date:  1995-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Affiliation:
Hormone Research Institute, University of California, San Francisco 94143-0534, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosomes, Human, Pair 11
DNA, Satellite / genetics
DNA-Binding Proteins
Diabetes Mellitus, Type 1 / genetics*
Humans
Insulin / genetics*
Islets of Langerhans / metabolism
Linkage (Genetics)
Minisatellite Repeats
Molecular Sequence Data
Polymorphism, Genetic
Promoter Regions, Genetic
Transcription Factors / metabolism
Transcription, Genetic
Chemical
Reg. No./Substance:
0/DNA, Satellite; 0/DNA-Binding Proteins; 0/Transcription Factors; 0/c-MYC-associated zinc finger protein; 11061-68-0/Insulin
Comments/Corrections
Comment In:
Nat Genet. 1995 Aug;10(4):378-80   [PMID:  7670485 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the ins...
Next Document:  A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes ...