Document Detail

The minimum alveolar concentration of nitrous oxide in man.
MedLine Citation:
PMID:  7201254     Owner:  NLM     Status:  MEDLINE    
The potency and anesthetic state produced by nitrous oxide alone were investigated in order to clarify its contribution to the effect of other anesthetic agents. Seven volunteers anesthetized with 1.55 atm absolute N2O in a pressure chamber displayed muscle rigidity with jerking movements, labored and rapid breathing, sweating, and dilated pupils. At 1.1 atm absolute N2O, relaxation and quiescence occurred, sweating ceased, and pupil size decreased. Determination of MAC (using tetanic electrical impulses as the noxious stimulus) produced a mean value of 1.04 +/- 0.10 (SE) atm absolute. All subjects complained of nausea and vomiting after anesthesia.
T F Hornbein; E I Eger; P M Winter; G Smith; D Wetstone; K H Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  61     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-6     Citation Subset:  AIM; IM    
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MeSH Terms
Atmospheric Pressure
Dose-Response Relationship, Drug
Movement / drug effects
Nausea / chemically induced
Nitrous Oxide / administration & dosage*,  adverse effects
Pulmonary Alveoli
Vomiting / chemically induced
Grant Support
Reg. No./Substance:
10024-97-2/Nitrous Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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