Document Detail


The minimum alveolar concentration of desflurane in cats.
MedLine Citation:
PMID:  8585150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight adult cats, 4 male and 4 female, (3.5 +/- 0.9 [SD] kg) were used to determine the minimum alveolar concentration (MAC) of desflurane. Desflurane (DES) anesthesia was induced in a 20 L chamber with an oxygen inflow of 10 L/min and the DES vaporizer set at 18%. After 3.5 +/- 0.5 min, the cats were removed from the chamber and anesthesia was maintained via mask (14% DES, 3L/min O2) until successful intubation. Anesthesia was maintained with DES in oxygen at a flow of at least 200 mL/kg/min through a nonrebreathing circuit. The time from the start of induction to completion of intubation was 6.2 +/- 1.1 min. Esophageal temperature was maintained between 37.8 degrees C and 38.6 degrees C. Hand-collected end-tidal gas samples were obtained from a catheter positioned inside the lumen of the endotracheal tube. Inspired and end-tidal DES concentrations were measured with a Biochem 8100 anesthetic agent monitor that was calibrated with known gas standards and modified to accept hand-collected samples. A constant alveolar concentration of DES was maintained for at least 15 minutes, then a clamp was applied to the tail and the cat observed for gross purposeful movement. The end-tidal DES was then increased (if a positive response) or decreased (if a negative response) by 20% and the test repeated after 15 minutes of constant conditions. The final iteration was 10%. The MAC of DES in these cats was 9.79 +/- 0.70 vol %. The FA/FI ratio for desflurane was always greater than 0.97.
Authors:
R M McMurphy; D S Hodgson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  24     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, Kansas State University, College of Veterinary Medicine, Manhattan, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation / veterinary*
Anesthetics, Inhalation / administration & dosage,  analysis*,  metabolism
Animals
Cats / metabolism*
Female
Isoflurane / administration & dosage,  analogs & derivatives*,  analysis,  metabolism
Male
Pulmonary Alveoli / chemistry*,  metabolism
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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