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A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures.
MedLine Citation:
PMID:  23376336     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Complex partial seizures, which typically originate in limbic structures such as the amygdala, are often resistant to antiseizure medications. Our goal was to investigate the effects of chronic dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) derived from fish oil on seizure thresholds in the amygdala, as well as on blood and brain PUFA levels. The acute effects of injected n-3 PUFAs - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - were also tested in the maximal pentylenetetrazol (PTZ) seizure model. In amygdala-implanted subjects, fish oil supplementation significantly increased amygdaloid afterdischarge thresholds, as compared with controls at 3, 5, and 7months after the start of supplementation. Fish oil supplementation also increased serum EPA and DHA concentrations. DHA concentration in the pyriform-amygdala area increased in the fish-oil treated group by 17-34%, but this effect did not reach statistical significance (P=0.065). DHA significantly increased the latency to seizure onset in the PTZ seizure model, whereas EPA had no significant effect. These observations suggest that chronic dietary fish oil supplementation can raise focal amygdaloid seizure thresholds and that this effect is likely mediated by DHA rather than by EPA.
Authors:
Ameer Y Taha; Marc-Olivier Trepanier; Flaviu A Ciobanu; Nadeen M Taha; Muaz Ahmed; Qiudi Zeng; Waiyin I Cheuk; Bryan Ip; Elvis Filo; Brian W Scott; W M Burnham; Richard P Bazinet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-30
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  27     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  49-58     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M5S 1A8; University of Toronto Epilepsy Research Program, Toronto, ON, Canada M5S 1A8. Electronic address: a.taha@utoronto.ca.
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