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The minimal important difference for residual volume in patients with severe emphysema.
MedLine Citation:
PMID:  22441742     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Residual Volume measured by body plethysmography is a routine measurement in clinical pulmonary practice and is often an important outcome variable in clinical trials. However, it is not known which size of improvement can be regarded as being important in severe emphysema patients. Therefore, the aim of the study is to establish the Minimal Important Difference (MID) for Residual Volume in severe emphysema patients undergoing bronchoscopic lung volume reduction.Ninety-one severe emphysema patients were included. Residual Volume and Total Lung Capacity were measured by body plethysmography. MID estimates were calculated with anchor-based and distribution-based methods. FEV1, Six-Minute-Walk-Distance and SGRQ total score were used as anchors and Cohen's effect size was used as distribution-based method.The calculated MID estimates according to the different anchors and methods ranged between -0.31;-0.43 L for Residual Volume, -6.1;-8.6% for percentage change in Residual Volume from baseline and -2.8;-4.0% for RV%TLC.These MID estimates are useful for sample size determination of new studies on interventions aimed at reducing Residual Volume and for interpreting the results from clinical trials in severe emphysema patients.
Authors:
J E Hartman; N H T Ten Hacken; K Klooster; H M Boezen; M H G de Greef; Dirk-Jan Slebos
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-22
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
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