| The minimal important difference of exercise tests in severe COPD. | |
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MedLine Citation:
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PMID: 20693247 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surgery or medical care. The St George's Respiratory Questionnaire (domain and total scores) and University of California San Diego Shortness of Breath Questionnaire (total score) served as anchors for anchor-based MID estimates. In order to calculate distribution-based estimates, we used the standard error of measurement, Cohen's effect size and the empirical rule effect size. Anchor-based estimates for the 6MWD were 18.9 m (95% CI 18.1-20.1 m), 24.2 m (95% CI 23.4-25.4 m), 24.6 m (95% CI 23.4-25.7 m) and 26.4 m (95% CI 25.4-27.4 m), which were similar to distribution-based MID estimates of 25.7, 26.8 and 30.6 m. For MCEC, anchor-based estimates for the MID were 2.2 W (95% CI 2.0-2.4 W), 3.2 W (95% CI 3.0-3.4 W), 3.2 W (95% CI 3.0-3.4 W) and 3.3 W (95% CI 3.0-3.5 W), while distribution-based estimates were 5.3 and 5.5 W. We suggest a MID of 26 ± 2 m for 6MWD and 4 ± 1 W for MCEC for patients with severe COPD. |
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Authors:
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M A Puhan; D Chandra; Z Mosenifar; A Ries; B Make; N N Hansel; R A Wise; F Sciurba; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-06 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 37 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 784-90 Citation Subset: IM |
Affiliation:
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Dept of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. mpuhan@jhsph.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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N01HR76101/HR/NHLBI NIH HHS; N01HR76102/HR/NHLBI NIH HHS; N01HR76103/HR/NHLBI NIH HHS; N01HR76104/HR/NHLBI NIH HHS; N01HR76105/HR/NHLBI NIH HHS; N01HR76106/HR/NHLBI NIH HHS; N01HR76107/HR/NHLBI NIH HHS; N01HR76108/HR/NHLBI NIH HHS; N01HR76109/HR/NHLBI NIH HHS; N01HR76110/HR/NHLBI NIH HHS; N01HR76111/HR/NHLBI NIH HHS; N01HR76112/HR/NHLBI NIH HHS; N01HR76113/HR/NHLBI NIH HHS; N01HR76114/HR/NHLBI NIH HHS; N01HR76115/HR/NHLBI NIH HHS; N01HR76116/HR/NHLBI NIH HHS; N01HR76118/HR/NHLBI NIH HHS; N01HR76119/HR/NHLBI NIH HHS |
| Investigator | |
Investigator/Affiliation:
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A P Fishman / ; B A Bozzarello / ; A Al-Amin / ; M Katz / ; C Wheeler / ; E Baker / ; P Barnard / ; P Cagle / ; J Carter / ; S Chatziioannou / ; K Conejo-Gonzales / ; K Dubose / ; J Haddad / ; D Hicks / ; N Kleiman / ; M Milburn-Barnes / ; C Nguyen / ; M Reardon / ; J Reeves-Viets / ; S Sax / ; A Sharafkhaneh / ; O Wilson / ; C Young / ; R Espada / ; R Butanda / ; M Ellisor / ; P Fox / ; K Hale / ; E Hood / ; A Jahn / ; S Jhingran / ; K King / ; C Miller / ; I Nizami / ; T Officer / ; J Ricketts / ; J Rodarte / ; R Teague / ; K Williams / ; J Reilly / ; D Sugarbaker / ; C Fanning / ; S Body / ; S Duffy / ; V Formanek / ; A Fuhlbrigge / ; P Hartigan / ; S Hooper / ; A Hunsaker / ; F Jacobson / ; M Moy / ; S Peterson / ; R Russell / ; Diane Saunders / ; S Swanson / ; R McKenna / ; Z Mohsenifar / ; C Geaga / ; M Biring / ; S Clark / ; J Cutler / ; R Frantz / ; P Julien / ; M Lewis / ; J Minkoff-Rau / ; V Yegyan / ; M Joyner / ; M DeCamp / ; J Stoller / ; Y Meli / ; J Apostolakis / ; D Atwell / ; J Chapman / ; P DeVilliers / ; R Dweik / ; E Kraenzler / ; R Lann / ; N Kurokawa / ; S Marlow / ; K McCarthy / ; P McCreight / ; A Mehta / ; M Meziane / ; O Minai / ; M Steiger / ; K White / ; J Maurer / ; T Durr / ; C Hearn / ; S Lubell / ; P O'Donovan / ; R Schilz / ; M Ginsburg / ; B Thomashow / ; P Jellen / ; J Austin / ; M Bartels / ; Y Berkmen / ; P Berkoski / ; F Brogan / ; A Chong / ; G DeMercado / ; A DiMango / ; S Do / ; B Kachulis / ; A Khan / ; B Mets / ; M O'Shea / ; G Pearson / ; L Rossoff / ; S Scharf / ; M Shiau / ; P Simonelli / ; K Stavrolakes / ; D Tsang / ; D Vilotijevic / ; C Yip / ; M Mantinaos / ; K McKeon / ; J Pfeffer / ; N MacIntyre / ; R D Davis / ; J Howe / ; R E Coleman / ; R Crouch / ; D Greene / ; K Grichnik / ; D Harpole / ; A Krichman / ; B Lawlor / ; H McAdams / ; J Plankeel / ; S Rinaldo-Gallo / ; S Shearer / ; J Smith / ; M Stafford-Smith / ; V Tapson / ; M Steele / ; J Norten / ; J Utz / ; C Deschamps / ; K Mieras / ; M Abel / ; M Allen / ; D Andrist / ; G Aughenbaugh / ; S Bendel / ; E Edell / ; M Edgar / ; B Edwards / ; B Elliot / ; J Garrett / ; D Gillespie / ; J Gurney / ; B Hammel / ; K Hanson / ; L Hanson / ; G Harms / ; J Hart / ; T Hartman / ; R Hyatt / ; E Jensen / ; N Jenson / ; S Kalra / ; P Karsell / ; J Lamb / ; D Midthun / ; C Mottram / ; S Swensen / ; A-M Sykes / ; K Taylor / ; N Torres / ; R Hubmayr / ; D Miller / ; S Bartling / ; K Bradt / ; B Make / ; M Pomerantz / ; M Gilmartin / ; J Canterbury / ; M Carlos / ; P Dibbern / ; E Fernandez / ; L Geyman / ; C Hudson / ; D Lynch / ; J Newell / ; R Quaife / ; J Propst / ; C Raymond / ; J Whalen-Price / ; K Winner / ; M Zamora / ; R Cherniack / ; P Diaz / ; P Ross / ; T Bees / ; J Drake / ; C Emery / ; M Gerhardt / ; M King / ; D Rittinger / ; M Rittinger / ; K Naunheim / ; R Gerber / ; J Osterloh / ; S Borosh / ; W Chamberlain / ; S Frese / ; A Hibbit / ; M E Kleinhenz / ; G Ruppel / ; C Stolar / ; J Willey / ; F Alvarez / ; C Keller / ; G Criner / ; S Furukawa / ; A M Kuzma / ; R Barnette / ; Neil Brister / ; K Carney / ; W Chatila / ; F Cordova / ; G D'Alonzo / ; M Keresztury / ; K Kirsch / ; C Kwak / ; K Lautensack / ; M Lorenzon / ; U Martin / ; P Rising / ; S Schartel / ; J Travaline / ; G Vance / ; P Boiselle / ; Gerald O'Brien / ; A Ries / ; R Kaplan / ; C Ramirez / ; D Frankville / ; P Friedman / ; J Harrell / ; J Johnson / ; D Kapelanski / ; D Kupferberg / ; C Larsen / ; T Limberg / ; M Magliocca / ; F J Papatheofanis / ; D Sassi-Dambron / ; Melissa Weeks / ; M Krasna / ; H Fessler / ; I Moskowitz / ; T Gilbert / ; J Orens / ; S Scharf / ; D Shade / ; S Siegelman / ; K Silver / ; C Weir / ; C White / ; F Martinez / ; M Iannettoni / ; C Meldrum / ; W Bria / ; K Campbell / ; P Christensen / ; K Flaherty / ; S Gay / ; P Gill / ; P Kazanjian / ; E Kazerooni / ; V Knieper / ; T Ojo / ; L Poole / ; L Quint / ; P Rysso / ; T Sisson / ; M True / ; B Woodcock / ; L Zaremba / ; L Kaiser / ; J Hansen-Flaschen / ; M L Dempsey / ; A Alavi / ; T Alcorn / ; S Arcasoy / ; J Aronchick / ; S Aukberg / ; B Benedict / ; S Craemer / ; R Daniele / ; J Edelman / ; W Gefter / ; L Kotler-Klein / ; R Kotloff / ; D Lipson / ; W Miller / ; Richard O'Connell / ; S Opelman / ; H Palevsky / ; W Russell / ; H Sheaffer / ; R Simcox / ; S Snedeker / ; J Stone-Wynne / ; G Tino / ; P Wahl / ; J Walter / ; P Ward / ; D Zisman / ; J Mendez / ; A Wurster / ; J Luketich / ; C Witt / ; G Ayres / ; M Donahoe / ; C Fuhrman / ; R Hoffman / ; J Lacomis / ; J Sexton / ; W Slivka / ; D Strollo / ; E Sullivan / ; T Simon / ; C Wrona / ; G Wrona / ; M Brown / ; E George / ; R Keenan / ; T Kopp / ; L Silfies / ; J Benditt / ; D Wood / ; M Snyder / ; K Anable / ; N Battaglia / ; L Boitano / ; A Bowdle / ; L Chan / ; C Chwalik / ; B Culver / ; T Gillespy / ; D Godwin / ; J Hoffman / ; A Ibrahim / ; D Lockhart / ; S Marglin / ; K Martay / ; P McDowell / ; D Oxorn / ; L Roessler / ; M Toshima / ; S Golden / ; L Bosco / ; Y-P Chiang / ; C Clancy / ; H Handelsman / ; S M Berkowitz / ; T Carino / ; J Chin / ; J Baldwin / ; K McVearry / ; A Norris / ; S Shirey / ; C Sikora / ; S Sheingold / ; S Piantadosi / ; J Tonascia / ; P Belt / ; A Blackford / ; K Collins / ; B Collison / ; R Colvin / ; J Dodge / ; M Donithan / ; V Edmonds / ; G L Foster / ; J Fuller / ; J Harle / ; R Jackson / ; S Lee / ; C Levine / ; H Livingston / ; J Meinert / ; J Meyers / ; D Nowakowski / ; K Owens / ; S Qi / ; M Smith / ; B Simon / ; P Smith / ; A Sternberg / ; M Van Natta / ; L Wilson / ; R Wise / ; R M Kaplan / ; J S Schwartz / ; Y-P Chiang / ; M C Fahs / ; A M Fendrick / ; A J Moskowitz / ; D Pathak / ; S Ramsey / ; S Sheingold / ; A L Shroyer / ; J Wagner / ; R Yusen / ; S Ramsey / ; R Etzioni / ; S Sullivan / ; D Wood / ; T Schroeder / ; K Kreizenbeck / ; K Berry / ; N Howlader / ; E Hoffman / ; J Cook-Granroth / ; A Delsing / ; J Guo / ; G McLennan / ; B Mullan / ; C Piker / ; J Reinhardt / ; B Wood / ; J Sieren / ; W Stanford / ; J A Waldhausen / ; G Bernard / ; D DeMets / ; M Ferguson / ; E Hoover / ; R Levine / ; D Mahler / ; A J McSweeny / ; J Wiener-Kronish / ; O D Williams / ; M Younes / ; G Criner / ; C Soltoff / ; G Weinmann / ; J Deshler / ; D Follmann / ; J Kiley / ; M Wu / |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2011 Apr;37(4):755-6
[PMID:
21454895
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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