| The minigrafting test for vitiligo: detection of stable lesions for melanocyte transplantation. | |
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MedLine Citation:
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PMID: 7829707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Selected patients with stable and refractory vitiligo may consider melanocyte transplantation as a therapeutic alternative. A method to anticipate the response to surgical repair is not available. OBJECTIVE: We evaluated the pigment spread of minigrafts when implanted within achromic lesions of stable vitiligo as a test to identify good candidates for surgical repigmentation. METHODS: Four to six minigrafts of 1.0 to 1.2 mm were implanted within lesions of patients with unilateral (localized) and bilateral (generalized) vitiligo. Pigment spread was assessed 3 months later. RESULTS: Forty-seven subjects were examined. In unilateral vitiligo 19 of 20 patients (95%) had a positive test result in comparison with only 13 of 27 patients (48%) with bilateral vitiligo (p = 0.002). CONCLUSION: The minigrafting test is a reliable tool to identify patients with stable vitiligo who may respond to melanocyte transplantation. Unilateral (localized) vitiligo is the best indication for surgical repigmentation. |
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Authors:
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R Falabella; A Arrunategui; M I Barona; A Alzate |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 32 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-02-23 Completed Date: 1995-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 228-32 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Fundacion Valle del Lili, Cali, Columbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Age of Onset Female Follow-Up Studies Humans Male Melanins / metabolism Melanocytes / metabolism, transplantation* Recurrence Skin / metabolism, pathology Skin Pigmentation Skin Transplantation / methods Vitiligo / metabolism, pathology*, surgery* |
| Chemical | |
Reg. No./Substance:
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0/Melanins |
| Comments/Corrections | |
Comment In:
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J Am Acad Dermatol. 1995 Dec;33(6):1061-2
[PMID:
7490361
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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