Document Detail

A miniature glucose sensor, implantable in the blood stream.
MedLine Citation:
PMID:  7172987     Owner:  NLM     Status:  MEDLINE    
We have developed a miniature glucose sensor using an oxygen electrode with a glucose oxidase membrane. The special character of this sensor is that the electrodes can be placed in a blood vessel and can measure the glucose level directly from the arterial blood stream if placed into an external A-V shunt. Its second notable characteristic is that the enzyme membrane is covered with a semipermeable membrane, which partially allows passage of glucose but only sufficient oxygen. This sensor is able to respond to glucose concentrations of up to 700 mg/dl in blood. This sensor loses 10% of its activity at about 200 h of continuous use, and 30% after 400 h of use. While the sensor cannot be sterilized by conventional mechanical or gas methods, certain antibiotics can be used for sterilization. To shorten the response delay of the sensor during the decreasing phase of glucose concentration, a thinner membrane is under development.
T Kondo; K Ito; K Ohkura; K Ito; S Ikeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  5     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-21     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / analysis*
Electrodes, Implanted*
Enzymes, Immobilized / diagnostic use*
Glucose Oxidase / diagnostic use*
Glucose Tolerance Test
Membranes, Artificial
Oxygen / blood
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Enzymes, Immobilized; 0/Membranes, Artificial; 7782-44-7/Oxygen; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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