Document Detail


A mini review of qRT-rtPCR technology application in uncovering the mechanism of food allergy and in the search for novel interventions.
MedLine Citation:
PMID:  23286237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This mini review targets the inclusion of recent selected citations, between the year 2006 and 2012, that implement the qRT-rtPCR technology in their experimental designs, targeting the uncovering of the mechanism of food allergy. In addition, this same technology was implemented in specific experimental designs, aiming at finding novel nutritional, herbal medicine, and tolerance interventions against food allergy. The approach of using qRT-rtPCR technology helped in studying the dynamics of transcription of cytokines and chemokines in intestinal dendritic cells of the experimental animals during the allergic reaction to food. The suppression of transcription of specific cytokines or chemokines by nutritional, herbal medicine, and tolerance interventions was instrumental in the search for finding novel remedies for this health condition, that was traditionally managed by avoidance of offending foods in the diet.
Authors:
Elie K Barbour; Houssam A Shaib; Diana M Ahmadieh; Taha Kumosani; Shady K Hamadeh; Esam Azhar; Steve Harakeh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anti-inflammatory & anti-allergy agents in medicinal chemistry     Volume:  12     ISSN:  1875-614X     ISO Abbreviation:  Antiinflamm Antiallergy Agents Med Chem     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-13     Revised Date:  2014-09-03    
Medline Journal Info:
Nlm Unique ID:  101462262     Medline TA:  Antiinflamm Antiallergy Agents Med Chem     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemokines / genetics,  metabolism*
Cytokines / genetics,  metabolism*
Dendritic Cells / metabolism
Diet
Food Hypersensitivity / immunology*,  physiopathology,  therapy*
Humans
Immune Tolerance
Mice
Mice, Inbred BALB C
Reverse Transcriptase Polymerase Chain Reaction / methods*
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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