| A mineralocorticoid receptor mutation causing human hypertension. | |
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MedLine Citation:
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PMID: 11496062 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years, the study of monogenic forms of hypertension has added greatly to our understanding of the regulatory mechanisms affecting blood pressure. Recently, a novel such form of human hypertension caused by gain-of-function mutation in the mineralocorticoid receptor, the mediator of aldosterone-induced sodium transport in the distal nephron, has been described, with the notable finding being that pregnancy causes a severe worsening of blood pressure. In this review, the mechanism by which the mutation causes hypertension, and the implications these findings have for improved understanding of cardiovascular physiology and mineralocorticoid receptor biology, are discussed. |
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Authors:
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D S Geller |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 10 ISSN: 1062-4821 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-08-09 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 661-5 Citation Subset: IM |
Affiliation:
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Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. david.geller@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hypertension / genetics* Mutation / physiology* Pregnancy / physiology Receptors, Mineralocorticoid / genetics* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Mineralocorticoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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