| Is milk-borne insulin-like growth factor-I essential for neonatal development? | |
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MedLine Citation:
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PMID: 9164277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin-like growth factor-I (IGF-I), a polypeptide growth factor found in milk, is hypothesized to play a functional role in the growth and development of neonates, particularly the gastrointestinal tract. Considerable evidence, based on direct tracer studies with 125I-labeled IGF-I and measurements of circulating IGF-I concentrations in neonatal animals fed a range of IGF-I doses, indicates that the intestinal absorption of IGF-I and the possible effect on metabolism and somatic growth are negligible. However, studies in neonatal animals indicate that oral administration of pharmacological doses of IGF-I increases small intestinal mucosal growth, whereas oral IGF-I provided within the physiological range may enhance the development of intestinal lactase. Therefore, clinical trials exploring the therapeutic use of oral IGF-I as an intervention for preterm neonates and those with compromised intestinal function seem warranted. However, milk-borne IGF-I may not be essential for normal healthy infants, perhaps because endogenous IGF-I provides a sufficient stimulus for maintenance of gastrointestinal structure and function. Future studies should explore the significance of endogenous IGF-I and whether milk-borne IGF-I may be important under pathological conditions in which the endogenous IGF-I production may be compromised. |
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Authors:
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D G Burrin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: The Journal of nutrition Volume: 127 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-13 Completed Date: 1997-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 975S-979S Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / growth & development Digestive System / growth & development Humans Infant, Newborn / growth & development* Insulin-Like Growth Factor I / analysis, physiology* Intestinal Absorption Milk, Human / chemistry* |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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