Document Detail

Is milk-borne insulin-like growth factor-I essential for neonatal development?
MedLine Citation:
PMID:  9164277     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factor-I (IGF-I), a polypeptide growth factor found in milk, is hypothesized to play a functional role in the growth and development of neonates, particularly the gastrointestinal tract. Considerable evidence, based on direct tracer studies with 125I-labeled IGF-I and measurements of circulating IGF-I concentrations in neonatal animals fed a range of IGF-I doses, indicates that the intestinal absorption of IGF-I and the possible effect on metabolism and somatic growth are negligible. However, studies in neonatal animals indicate that oral administration of pharmacological doses of IGF-I increases small intestinal mucosal growth, whereas oral IGF-I provided within the physiological range may enhance the development of intestinal lactase. Therefore, clinical trials exploring the therapeutic use of oral IGF-I as an intervention for preterm neonates and those with compromised intestinal function seem warranted. However, milk-borne IGF-I may not be essential for normal healthy infants, perhaps because endogenous IGF-I provides a sufficient stimulus for maintenance of gastrointestinal structure and function. Future studies should explore the significance of endogenous IGF-I and whether milk-borne IGF-I may be important under pathological conditions in which the endogenous IGF-I production may be compromised.
D G Burrin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  127     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-13     Completed Date:  1997-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975S-979S     Citation Subset:  IM    
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
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MeSH Terms
Animals, Newborn / growth & development
Digestive System / growth & development
Infant, Newborn / growth & development*
Insulin-Like Growth Factor I / analysis,  physiology*
Intestinal Absorption
Milk, Human / chemistry*
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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