Document Detail

A middle-aged woman with logopenic progressive aphasia as a precursor of Alzheimer's disease: case report and review of the literature.
Jump to Full Text
MedLine Citation:
PMID:  22937339     Owner:  NLM     Status:  PubMed-not-MEDLINE    
PRIMARY PROGRESSIVE APHASIA IS A NEURODEGENERATIVE DISORDER THAT WAS RECENTLY CLASSIFIED INTO THREE TYPES: fluent (semantic), nonfluent, and logopenic. The logopenic variant is the least common one and is closely related to Alzheimer's disease in comparison to the other two variants that are closely related to frontotemporal dementia. We report the case of a middle-aged woman who presented to our center with progressive aphasia that was undiagnosed for two years. The patient's neurological evaluation including positron emission tomography is consistent with a logopenic variant of primary progressive aphasia.
Stephanie M Awad; Amer M Awad
Related Documents :
23285469 - Frenectomy: a review with the reports of surgical techniques.
23119379 - Malignant fibrous histiocytoma of maxilla - a report of five cases and review of litera...
24521529 - Post-infective pericarditis left ventricular pseudoaneurysm: a case report and review o...
24765559 - Paraneoplastic syndrome in hawai'i: a case of dermatomyositis associated with endometri...
16988319 - Case of the month: a case of airway obstruction following tenecteplase administration.
23662239 - Idiopathic unilateral adrenal haemorrhage and adrenal mass: a case report and review of...
22844839 - Dorsal pancreas agenesis and ductal adenocarcinoma: surgical implications of an extreme...
22105889 - Ovarian tumor-derived ectopic hyperprolactinemia.
21062609 - Disseminated superficial porokeratosis and pyoderma gangrenosum.
Publication Detail:
Type:  Journal Article     Date:  2011-09-29
Journal Detail:
Title:  Case reports in neurological medicine     Volume:  2011     ISSN:  2090-6676     ISO Abbreviation:  Case Rep Neurol Med     Publication Date:  2011  
Date Detail:
Created Date:  2012-08-31     Completed Date:  2012-08-31     Revised Date:  2013-02-21    
Medline Journal Info:
Nlm Unique ID:  101576451     Medline TA:  Case Rep Neurol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  450301     Citation Subset:  -    
Family Medicine Residency Program, Baton Rouge General Medical Center, Baton Rouge, LA 70806, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Case Report Neurol Med
Journal ID (iso-abbrev): Case Report Neurol Med
Journal ID (publisher-id): CRIM.NM
ISSN: 2090-6668
ISSN: 2090-6676
Publisher: Hindawi Publishing Corporation
Article Information
Download PDF
Copyright © 2011 S. M. Awad and A. M. Awad.
Received Day: 15 Month: 7 Year: 2011
Accepted Day: 6 Month: 8 Year: 2011
Print publication date: Year: 2011
Electronic publication date: Day: 29 Month: 9 Year: 2011
Volume: 2011E-location ID: 450301
ID: 3420623
PubMed Id: 22937339
DOI: 10.1155/2011/450301

A Middle-Aged Woman with Logopenic Progressive Aphasia as a Precursor of Alzheimer's Disease: Case Report and Review of the Literature
Stephanie M. Awad1
Amer M. Awad12*
1Family Medicine Residency Program, Baton Rouge General Medical Center, Baton Rouge, LA 70806, USA
2Baton Rouge Neurology Associates, Baton Rouge General Medical Center, 3600 Florida Boulevard, Baton Rouge, LA 70806, USA
Correspondence: *Amer M. Awad:
[other] Academic Editors: Ö. Ateş and M. Swash

1. Introduction

Primary progressive aphasia (PPA) is a spectrum of heterogeneous disorders that are characterized by slowly progressive neurodegeneration affecting mainly the language function [1].

The first description of isolated language deteriorations was probably made by Serieux in the late nineteenth century [2]. Comprehensive epidemiological studies are so far lacking to define the exact demographics of PPA. However, PPA is still considered a rare disease with variable progression rates, variable ages of onset and without remarkable gender preponderance.

There has been dramatic progress in our understanding of PPA in the last few decades thanks to the progress in neuropathology, neurogenetics, and neuropsychology. PPA was recently subclassified into three distinct types [3, 4]: progressive nonfluent aphasia (PNFA), semantic dementia (SD), and the recently described logopenic variant (LPA). The logopenic variant accounts for one-third of PPA cases [3]. In this paper we will discuss the case of a patient with LPA that has early Alzheimer's disease features as well.

2. Case Report

The patient is a 54-year-old left-handed Caucasian lady who was referred to our center for evaluation of speech difficulties. The patient noted a gradually progressing speech problem about two years prior to her presentation. Her main difficulties were related to word finding and inability to express herself very well with frequent pauses. Her comprehension was also affected, but much less than her fluency. In addition, she noted that her reading abilities were declining and her writing skills seemed to be deteriorating. The patient denied any history of weakness, trouble swallowing, trouble breathing, numbness, loss of vision, hearing, or balance. Her husband had thought that her short-term memory was also impaired. The patient's family history was significant for Alzheimer's disease that affected her aunt in her 80s. The patient denied any history of strokes, seizures, or head injury. No behavioral abnormalities were reported. Her medical exam was normal, except for high cortical abnormalities. Her cranial nerves, motor system, sensory system, and coordination system exams were normal. The patient scored 23/30 on the Montreal Cognitive Assessment Exam (MOCA). There was evidence of aphasia on detailed language examination that can be classified as global aphasia. The patient's fluency was decreased with word finding difficulties without agrammatism. Comprehension of isolated words was intact, whereas comprehension of complex sentences was impaired. Repetition and digit span was impaired as well. Naming was mildly affected. Short-term memory including episodic memory was impaired. Cues did not seem to help improve recall. Interestingly, visuospatial function was impaired in a very subtle way. The patient was able to copy a cube but only after several unsuccessful attempts.

Prior to being evaluated by us the patient underwent numerous tests that were reported to be normal including brain magnetic resonance imaging (MRI), comprehensive autoimmune panel, electroencephalography (EEG) and vitamin B12, folic acid, thyroid stimulating hormone (TSH), and rapid plasma reagin (RPR) tests. We evaluated the patient with positron emission tomography (PET) scan which showed hypometabolism in the bilateral parietal as well as temporal lobes (Figures 1(a), 1(b), and 1(c)).

The clinical findings along with the radiological findings are highly suggestive of logopenic primary progressive aphasia (LPA).

3. Discussion

Our patient's neurocognitive assessment is highly suggestive of LPA.

LPA was first described by Gorno-Tempini and his coworkers in 2004 [3]. The disorder typically presents with word finding difficulty with no agrammatism, impaired repetition, impaired comprehension of complex sentences with retained comprehension of isolated words [3, 4].

LPA typically involves an abnormality in the parietotemporal lobes, predominantly, the dominant side [36]. Our patient's PET scan revealed bilateral parietotemporal pathology, predominantly in the left side. This was consistent with the neuroimaging findings.

The majority of LPA cases show AD cerebrospinal fluid (CSF) biomarkers [7, 8]. CSF biomarkers were not yet available at the time of case reporting.

The histopathology of LPA is variable, but pathology of Alzheimer's disease is the most common finding. In the series reported in 2008 by Josephs and coinvestigators, all PPA patients whose pathology showed changes consistent with AD pathology belonged to the LPA group [9]. Other series found AD pathology in the majority of cases, including frontotemporal lobar dementia (FTLD) pathology, in about one-fifth of LPA phenotype [7, 8, 10, 11].

Our patient had very subtle findings that suggest very early AD-like mild visuospatial dysfunction and subtle cortical memory deficits. These findings predict AD-type pathology.

4. Conclusion

LPA is a rare neurodegenerative disorder that is closely related to Alzheimer's disease. The early symptoms are very subtle and require a high index of suspicion. Healthcare providers need to be aware of this entity and other entities that present with subtle cognitive abnormalities. Despite the lack of effective treatment, recruiting these patients to research is invaluable to help improve our understanding of the pathophysiology of the disease that should guide us one day to an effective treatment.

1. Mesulam MM. Slowly progressive aphasia without generalized dementiaAnnals of NeurologyYear: 19821165925987114808
2. Serieux P. On a case of pure verbal deafnessRevue MedicaleYear: 189313733750
3. Gorno-Tempini ML,Dronkers NF,Rankin KP,et al. Cognition and amatomy in three variants of primany progressive aphasiaAnnals of NeurologyYear: 200455333534614991811
4. Gorno-Tempini ML,Brambati SM,Ginex V,et al. The logopenic/phonological variant of primary progressive aphasiaNeurologyYear: 200871161227123418633132
5. Awad M,Warren JE,Scott SK,Turkheimer FE,Wise RJS. A common system for the comprehension and production of narrative speechJournal of NeuroscienceYear: 20072743114551146417959788
6. Wong PCM,Jin JX,Gunasekera GM,Abel R,Lee ER,Dhar S. Aging and cortical mechanisms of speech perception in noiseNeuropsychologiaYear: 200947369370319124032
7. Mesulam M,Wicklund A,Johnson N,et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasiaAnnals of NeurologyYear: 200863670971918412267
8. Rohrer JD,Ridgway GR,Crutch SJ,et al. Progressive logopenic/phonological aphasia: erosion of the language networkNeuroImageYear: 201049198499319679189
9. Josephs KA,Whitwell JL,Duffy JR,et al. Progressive aphasia secondary to Alzheimer disease vs FTLD pathologyNeurologyYear: 2008701253418166704
10. Grossman M,Xie SX,Libon DJ,et al. Longitudinal decline in autopsy-defined frontotemporal lobar degenerationNeurologyYear: 200870222036204518420483
11. Rabinovici GD,Jagust WJ,Furst AJ,et al. Aβ amyloid and glucose metabolism in three variants of primary progressive aphasiaAnnals of NeurologyYear: 200864438840118991338

Article Categories:
  • Case Report

Previous Document:  Intracranial hemorrhage revealing pseudohypoparathyroidism as a cause of fahr syndrome.
Next Document:  An unusual cause of pseudomedian nerve palsy.