Document Detail

A microscopic and biomechanical study of skin and soft tissue after repeated expansion.
MedLine Citation:
PMID:  19076195     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Conventional expansion inadequately restores damaged skin for patients with large areas of skin deficiency or who lack sources of normal skin. These patients require repeated skin expansions, but little is known about the outcomes of this procedure. OBJECTIVE: To evaluate the microscopic changes and biomechanical properties of skin and soft tissue after repeated expansion. MATERIALS AND METHODS: We prepared three groups of six pigs each: a conventional expansion group, a repeated expansion group, and a blank nonsurgical control group. We measured histology, ultrastructure, basic fibroblast growth factor (bFGF), stress-strain, stress relaxation, and stress strength. RESULTS: Skin obtained after conventional expansion and repeated expansion was basically healthy, but the microscopic and biomechanical properties differed from those of nonexpanded skin, especially in the repeated expansion group. CONCLUSION: Repeated skin expansion involves growth under stress, simultaneous injuries, and further repairs, with fibers showing more injury signs than cells. This article describes the microscopic changes and biomechanical properties that occur after repeated expansion.
Ran Huo; Wang Yang; Li Shangbin; Leng Tingting; Zhao Yang; Gao Feng; Yu Qingping; Zhang Wenhao
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Publication Detail:
Type:  Journal Article     Date:  2008-12-08
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  35     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-07     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-9     Citation Subset:  IM    
Department of Aesthetic, Plastic and Burn Surgery, Shandong Provincial Hospital, Jinan City, Shangdong Province, China.
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MeSH Terms
Fibroblast Growth Factors / analysis
Microscopy, Electron
Reconstructive Surgical Procedures / methods
Skin / chemistry*,  cytology*,  ultrastructure
Stress, Mechanical
Tissue Expansion
Reg. No./Substance:
62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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