Document Detail

A micropuncture study of the effect of isoprenaline on renal tubular fluid and electrolyte transport in the rat.
MedLine Citation:
PMID:  1143355     Owner:  NLM     Status:  MEDLINE    
To explain the mechanism of the isoprenaline induced antidiuresis the effect of this substance on fluid and electrolyte reabsorption in various nephron segments of the rat kidney has been studied using micropuncture techniques. Isoprenaline (1.5x10-9mol/kg-min i.v.) decreased GFR of superficial nephrons and increased fractional proximal fluid, sodium and potassium reabsorption. However, the fractions of filtered fluid and electrolytes, which had been reabsorbed up to early distal tubule were unchanged after isoprenaline. This indicated that the increased fractional proximal reabsorption has been completely compensated by decreased reabsorption from Henle's loops. In the distal convoluted tubules an increase in the fractional fluid and sodium reabsorption could be established using a recollection technique. Given directly into the distal tubular lumen isoprenaline stimulated the isotonic fluid reabsorption, which was measured by the Gertz split oil droplet method. From these results it is concluded that the decrease in superficial GFR and the increased distal tubular fluid and sodium reabsorption lead to the decrease in urine volume and in urinary electrolyte excretion after isoprenaline.
J Greven; O Heidenreich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  287     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1975  
Date Detail:
Created Date:  1975-10-10     Completed Date:  1975-10-10     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  117-28     Citation Subset:  IM    
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MeSH Terms
Biological Transport / drug effects
Diuresis / drug effects
Electrolytes / metabolism
Glomerular Filtration Rate / drug effects
Inulin / metabolism
Isoproterenol / pharmacology*
Kidney Tubules / drug effects*,  physiology
Kidney Tubules, Distal / drug effects
Kidney Tubules, Proximal / drug effects
Loop of Henle / physiology
Potassium / metabolism
Sodium / metabolism
Reg. No./Substance:
0/Electrolytes; 7440-09-7/Potassium; 7440-23-5/Sodium; 7683-59-2/Isoproterenol; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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