| A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system. | |
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MedLine Citation:
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PMID: 19629555 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2-3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema. |
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Authors:
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James Courtney Parker; Adel Sakla; Francis M Donovan; David Beam; Annu Chekuri; Mohammad Al-Khatib; Charles R Hamm; Fabien G Eyal |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-07-24 |
Journal Detail:
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Title: Medical & biological engineering & computing Volume: 47 ISSN: 1741-0444 ISO Abbreviation: Med Biol Eng Comput Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704869 Medline TA: Med Biol Eng Comput Country: United States |
Other Details:
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Languages: eng Pagination: 931-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of South Alabama, MSB 3074, Mobile, AL 36688, USA. jparker@usouthal.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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2 R42 HL57040/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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