Document Detail


The microinjection of AMPA receptor antagonist into the accumbens shell failed to change food intake, but reduced fear-motivated behaviour in free-feeding female rats.
MedLine Citation:
PMID:  18586053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the effect of the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 2.5 and 5.0 nmol/side) microinjected into the core and shell sub-regions of the accumbens (Acb) nucleus, on food intake and the level of anxiety in female rats. Bilateral microinjections of CNQX (5.0 nmol/side) into the Acb shell (AP, +1.08 to +2.04), but not into the Acb core, induced an anxiolytic-like effect in relation to rats microinjected with vehicle, since the animals exhibited low level of SAP in the feeding test. The anxiolytic-like effect induced by 5.0 nmol CNQX microinjection into the Acb shell may not be ascribed to changes in the motor activity of the animals, because the frequency of locomotion, rearing and grooming remained unchanged after the drug microinjection. However, neither Acb shell nor Acb core CNQX microinjections were able to change the animals food intake along 1h feeding behaviour evaluation. Food intake remained unchanged 24h after the drug microinjections either into the Acb shell or into the Acb core. The data suggest that AMPA receptor blockade in the Acb nucleus may differentially change the ingestive and defensive behaviours in female rats.
Authors:
Isabel Cristina da Cunha; Aparecida Marcelino de Nazareth; Juliano Cordova Vargas; Adriana Ferraz; José Marino Neto; Marta Aparecida Paschoalini; Moacir Serralvo Faria
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Publication Detail:
Type:  Journal Article     Date:  2008-06-08
Journal Detail:
Title:  Behavioural brain research     Volume:  193     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, Centre of Biological Sciences, Federal University of Santa Catarina (UFSC), Campus Trindade, 88.040-900 Florianópolis, SC, Brazil.
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MeSH Terms
Descriptor/Qualifier:
6-Cyano-7-nitroquinoxaline-2,3-dione / administration & dosage,  pharmacology*
Analysis of Variance
Animals
Anxiety / physiopathology,  psychology
Behavior, Animal / drug effects,  physiology
Dose-Response Relationship, Drug
Eating / drug effects*,  physiology
Excitatory Amino Acid Antagonists / administration & dosage,  pharmacology
Exploratory Behavior / drug effects,  physiology
Fear / psychology
Female
Food Preferences / drug effects,  physiology
Grooming / drug effects,  physiology
Microinjections
Motor Activity / drug effects*,  physiology
Nucleus Accumbens / drug effects*,  metabolism
Rats
Rats, Wistar
Receptors, AMPA / antagonists & inhibitors*
Time Factors
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Receptors, AMPA; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione

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