Document Detail


A microgranular variant of acute promyelocytic leukemia with atypical morpho-cytochemical features and an early myeloid immunophenotype.
MedLine Citation:
PMID:  9279368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13 (+), CD33 (+), CD9 (+), CD2 (+), HLA-DR (-), CD34 (+), CD117 (+), and TdT (+). The diagnosis of AML M3 variant was made only after genotypic analyses revealed the PML/RAR alpha rearrangement associated with the typical (15;17) (q22;q21) translocation. This example of 'asynchronous differentiation' emphasizes the need for a multiparameter approach to the diagnosis of acute leukemia.
Authors:
R Stasi; A Bruno; A Venditti; G Del Poeta; G Aronica; M C Cox; L Maffei; G Catalano; D Zangrilli; S Amadori
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia research     Volume:  21     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  IM    
Affiliation:
Chair of Hematology, University of Rome Tor Vergata, S. Eugenio Hospital, Italy. mc2558@mclink.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / immunology
Chromosome Aberrations
Histocytochemistry
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Promyelocytic, Acute / genetics,  immunology,  pathology*
Male
Chemical
Reg. No./Substance:
0/Antigens, CD

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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