Document Detail

The microglial system in the eye and brain in response to stimuli in vivo.
MedLine Citation:
PMID:  23733124     Owner:  NLM     Status:  In-Data-Review    
Microglial cells function as first responders to signal inflammation, react to injuries by creating a wall to block invaders, and clear debris from the site. To better understand the modulation of microglia in inflammation and injury of eye and brain, we developed a morphological and orienting classification system of each stage of microglia, calling it the 'Spider Effect'. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. This relates to inflammation in the eye due to noxious stimuli, injury, or increase in pressure. Future studies may address the reported modulation of the microglial system in retina and optic nerve head in acute and chronic glaucoma.
Rutledge G Ellis-Behnke; Rahul A Jonas; Jost B Jonas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  22 Suppl 5     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2013 Jun-Jul
Date Detail:
Created Date:  2013-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S32-5     Citation Subset:  IM    
*Department of Ophthalmology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany †Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA.
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