| A microcomputer program for individualizing factor VIII dosage in hemophilia patients undergoing major surgery. | |
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MedLine Citation:
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PMID: 3091315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pharmacokinetic program that allows individualization of Factor VIII dosage regiments in hemophilia patients undergoing major surgery is described. The program, which is designed for the IBM PC microcomputer and compatible machines, is based upon the one-compartment open model with instantaneous input. In the framework of such a pharmacokinetic model, it is assumed that the elimination of Factor VIII is faster during the early post-operative period and that it decreases progressively over the following days. Since Factor VIII half-life is dependent on the time elapsed since the operation (short half-life values during the early post-operative period, longer half-life values thereafter), the pharmacokinetic model is a nonlinear one. A first-order 'variation' rate constant is used to describe the prolongation of Factor VIII half-life from the initial value immediately after surgery to the final value achieved several days later. Individualized estimation of the patient's kinetic parameters (initial half-life, 'variation' rate constant and volume of distribution) is performed through the Bayesian method. Therefore, for such estimation the program exploits the Factor VIII plasma levels measured in the individual patient as well as the population pharmacokinetic data of Factor VIII. After estimating the individual's Bayesian parameters, the program predicts the dosage regimen that will elicit the desired time-course of Factor VIII plasma levels. If requested, the program is able to calculate the least-squares estimates for the parameters of the pharmacokinetic model and dosage prediction can also be made on the basis of such estimates. The least-squares estimates are useful for calculating population pharmacokinetic parameters according to the Standard Two-Stage method. Some examples of clinical use of the program are presented. |
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Authors:
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S Ruffo; A Messori; G Longo; M Matucci; M Morfini; P Rossi-Ferrini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Computer methods and programs in biomedicine Volume: 23 ISSN: 0169-2607 ISO Abbreviation: Comput Methods Programs Biomed Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-10-22 Completed Date: 1986-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8506513 Medline TA: Comput Methods Programs Biomed Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 37-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Computers* Factor VIII / administration & dosage*, metabolism Hemophilia A / drug therapy*, metabolism Humans Kinetics Microcomputers Models, Biological Software* Surgical Procedures, Operative* |
| Chemical | |
Reg. No./Substance:
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9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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