Document Detail

A microcomputer program for evaluating sampling error: an application to stereological methods for electron microscopy.
MedLine Citation:
PMID:  1617005     Owner:  NLM     Status:  MEDLINE    
In situations where there is a need to minimize sampling error or sample size, the coefficient of variation (CV) may be used to evaluate sampling error as a function of the number of observations or subjects in a sample. For example, CV is useful for estimating the minimum number of electron micrographs (Nmin) required to obtain a representative field sample for stereological analysis. To facilitate the determination of Nmin, we have written a program (COEFficient) for DOS microcomputers which calculates CVs. COEF assists the user in reducing error to that which solely reflects biological variability, thereby minimizing the time and cost of subsequent analyses.
G Herbener; R Goodfliesh; B Fass-Holmes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biotechnic & histochemistry : official publication of the Biological Stain Commission     Volume:  67     ISSN:  1052-0295     ISO Abbreviation:  Biotech Histochem     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107378     Medline TA:  Biotech Histochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Kentucky 40292.
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MeSH Terms
Microscopy, Electron / methods*
Specimen Handling / standards*
Statistics as Topic
Grant Support

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