| A microcomputer-assisted study of nabumetone and slow release diclofenac in osteoarthritis. | |
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MedLine Citation:
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PMID: 2081489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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20 UK general-practice centres entered 243 patients into a 6-week double-blind, double-dummy, randomised, parallel-group trial designed to compare nabumetone 1 g at night with slow release diclofenac 100mg at night in the treatment of osteoarthritis. Seven efficacy parameters were measured, adverse events were recorded and laboratory monitoring was performed. The study monitor entered trial data into a portable laptop microcomputer at the participating centres. Both treatment groups showed highly significant clinical improvements at the end of the 6-week study period and there were no significant inter-group differences. Overall, the incidence of adverse events was similar in the 2 groups, but significantly fewer patients in the nabumetone group (n = 21) than in the diclofenac group (n = 35) complained of gastrointestinal adverse events (p = 0.03). On-site use of the microcomputer contributed to increased monitoring efficiency and trialist motivation, resulting in rapid recruitment of patients, collection of high quality data and speedy analysis at the end of the study. |
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Authors:
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D Laws; S Saul; B Fehilly |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Drugs Volume: 40 Suppl 5 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1990 |
Date Detail:
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Created Date: 1991-05-09 Completed Date: 1991-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Herrington House, Houghton-le-Spring, Tyne and Wear, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use* Butanones / adverse effects, therapeutic use* Delayed-Action Preparations Diclofenac / administration & dosage, adverse effects, therapeutic use* Double-Blind Method Female Humans Male Microcomputers* Middle Aged Osteoarthritis / drug therapy* Pain Measurement |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Butanones; 0/Delayed-Action Preparations; 15307-86-5/Diclofenac; 42924-53-8/nabumetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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