| Is microbubble-enhanced ultrasonography sufficient for assessment of response to percutaneous treatment in patients with early hepatocellular carcinoma? | |
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MedLine Citation:
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PMID: 16710666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to assess the efficacy of contrast-enhanced ultrasonography (CEUS) with SonoVue to evaluate the response to percutaneous treatment (ethanol injection/radiofrequency) of hepatocellular carcinoma in comparison with spiral computed tomography (CT) immediately and 1 month after treatment. Forty-one consecutive cirrhotic patients with early stage tumor (not suitable for resection) were included. Spiral CT and CEUS were performed in all patients before treatment, in the following 24 h, and 1 month later. The results of each examination were compared with the 1-month spiral CT, considered the gold standard technique. The 24-h CEUS and the 24-h spiral CT sensitivity to detect residual disease were 27% and 20%, respectively. The 24-h CEUS and the 24-h spiral CT positive predictive value of persistent vascularization detection were 75% and 66%, respectively. The 1-month CEUS detected partial responses in ten out of 11 cases (91% sensitivity, 97% specificity, 95% accuracy). Spiral CT and CEUS performed in the 24 h following treatment are slightly useful to evaluate therapeutic efficacy. The 1-month CEUS has a high diagnostic accuracy compared with spiral-CT in the usual assessment of percutaneous treatment response. |
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Authors:
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R Vilana; L Bianchi; M Varela; C Nicolau; M Sánchez; C Ayuso; M García; M Sala; J M Llovet; J Bruix; C Bru; |
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Publication Detail:
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Type: Journal Article Date: 2006-05-18 |
Journal Detail:
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Title: European radiology Volume: 16 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2007-07-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2454-62 Citation Subset: IM |
Affiliation:
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Diagnosis Imaging Center, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain. rvilana@clinic.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Aged Carcinoma, Hepatocellular / pathology*, radiography, surgery, ultrasonography* Catheter Ablation* Central Nervous System Depressants / therapeutic use Ethanol / therapeutic use False Positive Reactions Female Follow-Up Studies Humans Image Enhancement* Image Processing, Computer-Assisted Liver Neoplasms / pathology*, radiography, surgery, ultrasonography* Male Microbubbles* Middle Aged Neoplasm Staging Phospholipids / administration & dosage, diagnostic use, metabolism Prospective Studies Sensitivity and Specificity Sulfur Hexafluoride / administration & dosage, diagnostic use, metabolism Time Factors Tomography, Spiral Computed Treatment Outcome Tumor Burden Ultrasonography, Interventional / methods* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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