Document Detail

 Gut microbiota and nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  22700625     Owner:  NLM     Status:  MEDLINE    
 Recent evidence has linked obesity and the metabolic syndrome with gut dysbiota. The precise mechanisms underlying that association are not entirely understood; however, microbiota can enhance the extraction of energy from diet and regulate whole-body metabolism towards increased fatty acids uptake from adipose tissue and shift lipids metabolism from oxidation to de novo production. Obesity and high fat diet relate to a specific gut microbiota, which is enriched in Firmicutes and with less Bacterioidetes. Microbiota can also play a role in the development of hepatic steatosis, necroinflammation and fibrosis. In fact, some studies have shown an association between small intestinal bacterial overgrowth, increased intestinal permeability and nonalcoholic steatohepatitis (NASH). That association is, in part, due to increased endotoxinaemia and activation of the Toll-like receptor-4 signaling cascade. Preliminary data on probiotics suggest a potential role in NASH treatment, however randomized controlled clinical trials are still lacking.
Mariana V Machado; Helena Cortez-Pinto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-22     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  440-9     Citation Subset:  IM    
Departamento de Gastrenterologia, Hospital Santa Maria, CHLN, Lisbon, Portugal.
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MeSH Terms
Bacteria / growth & development*,  metabolism
Dietary Carbohydrates / metabolism
Energy Metabolism
Fatty Liver / metabolism,  microbiology*,  therapy
Fructose / metabolism
Intestines / microbiology*
Obesity / metabolism,  microbiology
Probiotics / therapeutic use
Risk Factors
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Prebiotics; 30237-26-4/Fructose
Comment In:
Ann Hepatol. 2013 Jan-Feb;12(1):161-3   [PMID:  23293210 ]

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