Document Detail


The microbiota in inflammatory bowel disease in different age groups.
MedLine Citation:
PMID:  19786749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many efforts were made in the past decades to assess the role of gut microbiota in inflammatory bowel diseases (IBD), leading to the hypothesis that an altered microbial composition, other than the presence of a specific pathogen, could be involved in the pathogenesis of the disease. On the other hand, existing differences in gut microbial community between distinct classes of age make sense of an increasing research in microbial shifts in IBD.
METHODS: Cultural, molecular, metabolomic and metagenomic approaches are trying to define the human gut microbiota in different age groups.
RESULTS AND CONCLUSION: An increase in anaerobic bacteria (Bacteroidesvulgatus, Streptococcus faecalis) was observed in adult IBD, whereas an increase in aerobic and facultative-anaerobic (Escherichia coli) was found in pediatric IBD. Overall higher bacterial cell counts were observed in IBD, jointly with a general loss of biodiversity and a preponderance of Bacteroidetes and a parallel decrease of Firmicutes phylum: a predominance of potential harmful members of Proteobacteria (E. coli) and low abundance of beneficial species (Faecalibacterium prausnitzii) was also reported in pediatric and adult age groups, respectively. Microbial community of elderly subjects contains a wider range of different species than those of children and adults, both in healthy and IBD status.
Authors:
Salvatore Cucchiara; Valerio Iebba; Maria Pia Conte; Serena Schippa
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Publication Detail:
Type:  Journal Article; Retracted Publication; Review     Date:  2009-09-24
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  27     ISSN:  1421-9875     ISO Abbreviation:  Dig Dis     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-29     Completed Date:  2009-12-02     Revised Date:  2014-10-31    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  252-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aging*
Gastrointestinal Tract / microbiology,  pathology
Humans
Inflammatory Bowel Diseases / microbiology*
Metagenome / physiology*
Comments/Corrections
Retraction In:
Dig Dis. 2014;32(3):312   [PMID:  24732198 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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