Document Detail

The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens.
MedLine Citation:
PMID:  20230854     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. METHODS: We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardised surgical sampling protocol was used. RESULTS: Staphylococcus aureus was most commonly isolated (32%) amongst a wide range of organisms including gram negative bacilli, anaerobes and coagulase negative staphylococci. Low grade pathogens were not confined to patients with a history of metalwork, a high proportion of cases were polymicrobial (29%) and culture negative cases were common (28%). No clear predictors of causative organism could be established. Many isolates were found to be resistant to commonly used empirical anti-microbial regimens. CONCLUSIONS: The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of extensive intra-operative sampling and provides important information to guide clinicians' choice of empirical antibiotics.
S H Sheehy; B A Atkins; P Bejon; I Byren; D Wyllie; N A Athanasou; A R Berendt; M A McNally
Related Documents :
12369064 - Superbugs ii: how should economic evaluation be conducted for interventions which aim t...
16524424 - Ceftobiprole: in-vivo profile of a bactericidal cephalosporin.
20015394 - Microbiological evaluation of the efficacy of two new biodetergents on multidrug-resist...
15164964 - Antibiotic susceptibility of bacteria most commonly isolated from bone related infectio...
7574654 - In vitro h2 utilization by a ruminal acetogenic bacterium cultivated alone or in associ...
9158264 - A clinical comparison of typhoid fever caused by susceptible and multidrug-resistant st...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-15
Journal Detail:
Title:  The Journal of infection     Volume:  60     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.
Department of Microbiology & Infectious Diseases, Oxford Radcliffe Hospitals' Trust, Oxford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / pharmacology,  therapeutic use*
Bacteria / classification*,  drug effects,  isolation & purification
Bacterial Infections / epidemiology*,  microbiology*
Chronic Disease / epidemiology
Drug Resistance, Bacterial*
Great Britain / epidemiology
Middle Aged
Osteomyelitis / microbiology*
Prospective Studies
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The residues 35proline and 41cysteine of chicken IL-2 are critical for binding to chicken CD25.
Next Document:  LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.