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The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM.
MedLine Citation:
PMID:  21663889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: We sought to determine whether there is an association between bacterial load of genital mycoplasmas and histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN: A total of 103 women with PPROM between 24-36 weeks of gestation were included in the study. Amniocenteses were performed, and the amounts of target genital mycoplasma DNA in amniotic fluid samples were evaluated using real-time polymerase chain reaction. The bacterial load of the genital mycoplasmas was relatively assessed using the threshold cycle value. RESULTS: The presence of genital mycoplasmas in amniotic fluid was found in 38% (39/103) of the women. The presence of HCA was associated with lower threshold cycle values (median 21.3, interquartile range, 16.5-28.5, vs median 29.4, interquartile range, 27.0-30.5; P = .005). CONCLUSION: HCA in PPROM is associated with a higher bacterial load of genital mycoplasmas.
Authors:
Marian Kacerovsky; Lenka Pliskova; Radka Bolehovska; Ivana Musilova; Helena Hornychova; Vojtech Tambor; Bo Jacobsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-24
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Charles University in Prague, Prague, Czech Republic.
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