Document Detail


The microanatomy of spinal cord injury: A review.
MedLine Citation:
PMID:  25044123     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Spinal cord injury is a highly prevalent condition associated with significant morbidity and mortality. The pathophysiology underlying it is extraordinarily complex and still not completely understood. We performed a comprehensive literature review of the pathophysiologic processes underlying spinal cord injury. The mechanisms underlying primary and secondary spinal cord injury are distinguished based on a number of factors and include the initial mechanical injury force, the vascular supply of the spinal cord which is associated with spinal cord perfusion, spinal cord autoregulation, and post-traumatic ischemia, and a complex inflammatory cascade involving local and infiltrating immunomodulating cells. This review illustrates the current literature regarding the pathophysiology behind spinal cord injury and outlines potential therapeutic options for reversing these mechanisms. Clin. Anat., 2014. © 2014 Wiley Periodicals, Inc.
Authors:
Martin M Mortazavi; Ketan Verma; Olivia A Harmon; Christoph J Griessenauer; Nimer Adeeb; Nicholas Theodore; R Shane Tubbs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-11
Journal Detail:
Title:  Clinical anatomy (New York, N.Y.)     Volume:  -     ISSN:  1098-2353     ISO Abbreviation:  Clin Anat     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809128     Medline TA:  Clin Anat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc.
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