Document Detail


microRNAs and death receptors.
MedLine Citation:
PMID:  18490189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Death receptors induce apoptosis through either the Type I or II pathway. In Type I cells, the initiator caspase-8 directly activates effector caspases such as caspase-3, whereas in Type II cells, the death signal is amplified through mitochondria thereby activating effector caspases causing cell death. Recently, there have been advances in elucidating the early events in the CD95 signaling pathways and how post-translational modifications regulate CD95 signaling. This review will focus on recent insights into the mechanisms of the two different types of CD95 signaling pathways, and will introduce miRNAs as regulators of death receptor signaling.
Authors:
Sun-Mi Park; Marcus E Peter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-19
Journal Detail:
Title:  Cytokine & growth factor reviews     Volume:  19     ISSN:  1359-6101     ISO Abbreviation:  Cytokine Growth Factor Rev.     Publication Date:    2008 Jun-Aug
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-11     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9612306     Medline TA:  Cytokine Growth Factor Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD95 / metabolism*
Antineoplastic Agents / pharmacology
Apoptosis*
MicroRNAs / metabolism,  physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 GM061712/GM/NIGMS NIH HHS; R01 GM061712-08/GM/NIGMS NIH HHS; R01 GM61712/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Antineoplastic Agents; 0/MicroRNAs; 0/let-7 microRNA, C elegans
Comments/Corrections

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