Document Detail


microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming.
MedLine Citation:
PMID:  22674461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emerging evidence suggests that microRNA (miRNA)-mediated post-transcriptional gene regulation plays an essential role in modulating embryonic stem (ES) cell pluripotency maintenance, differentiation, and reprogramming of somatic cells to an ES cell-like state. Investigations from ES cell-enriched miRNAs, such as mouse miR-290 cluster and human miR-302 cluster, and ES cell-depleted miRNAs such as let-7 family miRNAs, revealed a common theme that miRNAs target diverse cellular processes including cell cycle regulators, signaling pathway effectors, transcription factors, and epigenetic modifiers and shape their protein output. The combinatorial effects downstream of miRNA action allow miRNAs to modulate cell-fate decisions effectively. Furthermore, the transcription and biogenesis of miRNAs are also tightly regulated. Thus, elucidating the interplay between miRNAs and other modes of gene regulation will shed new light on the biology of pluripotent stem cells and somatic cell reprogramming.
Authors:
Meng Amy Li; Lin He
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-05
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  34     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-11-07     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  670-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Cell Differentiation
Embryonic Stem Cells / cytology*
Epithelial-Mesenchymal Transition
Gene Expression Regulation
Humans
MicroRNAs / genetics,  metabolism*
Pluripotent Stem Cells / cytology*
RNA Interference
RNA, Messenger / genetics,  metabolism
Signal Transduction
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
R01 CA139067/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Messenger
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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