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microRNA and Human Inducible Nitric Oxide Synthase.
MedLine Citation:
PMID:  25189382     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Regulation of human inducible nitric oxide synthase (iNOS) expression involves both transcriptional and posttranscriptional mechanisms. Human iNOS gene transcription is controlled in a cell type-specific manner by extracellular cytokines. Transcriptional regulation of human iNOS gene involves transcription factors NF-κB, Stat-1, AP-1, C/EBPβ, KLF6, Oct 1, and NRF. Important posttranscriptional mechanisms also regulate human iNOS mRNA stability through RNA binding proteins HuR, TTP, KSRP, and PABP. Recently, there are several miRNAs that were validated to regulate human and rodent iNOS gene expression. Among them, miR-939 and miR-26a were identified to bind with the human iNOS 3'-UTR and exert a translational blockade of human iNOS protein synthesis.
Authors:
Zhong Guo; David A Geller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vitamins and hormones     Volume:  96     ISSN:  0083-6729     ISO Abbreviation:  Vitam. Horm.     Publication Date:  2014  
Date Detail:
Created Date:  2014-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413601     Medline TA:  Vitam Horm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
Copyright Information:
© 2014 Elsevier Inc. All rights reserved.
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