Document Detail

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C.
MedLine Citation:
PMID:  21468029     Owner:  NLM     Status:  MEDLINE    
Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.
Elisa Penna; Francesca Orso; Daniela Cimino; Enrico Tenaglia; Antonio Lembo; Elena Quaglino; Laura Poliseno; Adele Haimovic; Simona Osella-Abate; Cristiano De Pittà; Eva Pinatel; Michael B Stadler; Paolo Provero; Maria Grazia Bernengo; Iman Osman; Daniela Taverna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-05
Journal Detail:
Title:  The EMBO journal     Volume:  30     ISSN:  1460-2075     ISO Abbreviation:  EMBO J.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-19     Completed Date:  2011-07-26     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1990-2007     Citation Subset:  IM    
Molecular Biotechnology Center (MBC), University of Torino, Torino, Italy.
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MeSH Terms
Cell Movement
Cell Proliferation
Cell Survival
Cells, Cultured
Gene Expression Regulation*
Integrins / metabolism
Lung / pathology
Lung Neoplasms / pathology
Melanoma / pathology*,  secondary*
MicroRNAs / genetics,  metabolism*
Neoplasm Metastasis / pathology*
Transcription Factor AP-2 / biosynthesis*
Reg. No./Substance:
0/Integrins; 0/MIRN214 microRNA, human; 0/MicroRNAs; 0/TFAP2C protein, human; 0/Transcription Factor AP-2
Comment In:
EMBO J. 2011 May 18;30(10):1880-1   [PMID:  21593728 ]

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