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microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells.
MedLine Citation:
PMID:  22716245     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Overexpression of microRNA-21 (miR-21) has been observed in various cancer types, but little is known about the role of miR-21 in melanoma. In this study, we demonstrate that levels of miR-21 are significantly increased in primary melanoma tissues as compared to benign nevi and in human melanoma cell lines as compared to melanocytic cell preparations. We show that downregulation of miR-21 in melanoma cell lines with high endogenous miR-21 expression induced apoptosis, whereas proliferation was not significantly altered. Upregulation of miR-21 in melanocytes resulted in increased proliferation and decreased apoptosis. However, in the MEWO melanoma cells with low endogenous miR-21 expression, upregulation of miR-21 had no functional effects. These findings indicate a potential pathogenetic role of miR-21 upregulation in a subgroup of melanomas.
Authors:
Imke Satzger; Anika Mattern; Uta Kuettler; Dirk Weinspach; Margarete Niebuhr; Alexander Kapp; Ralf Gutzmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  509-14     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany.
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